PhD Position Single-Molecule Biophysics

PhD Position Single-Molecule Biophysics

We are seeking a motivated PhD student to use single-molecule techniques and computational tools to explore molecular interactions and apply them for therapeutic applications.

Job description

We are looking for a PhD student passionate about understanding molecular mechanisms in biological systems. This position involves applying single-molecule techniques to study molecular interactions, including protein-ligand interactions and protein-peptide interactions. The candidate will work in an interdisciplinary environment, combining experimental approaches (single molecule fluorescence and biochemistry) with computational methods. The candidate will obtain single-molecule multiplexing data and validate machine learning predictions using the high-throughput data. The successful candidate will collaborate with international partners for therapeutic applications of this research. The project offers opportunities to make significant contributions to understanding molecular interactions and their implications for both fundamental and medical sciences.

Job requirements

• MSc degree (or nearing completion) in physics, biophysics, computational biology, or a related field.
• Strong programming skills (Python) and experience in data analysis and computational methods.
• Familiarity with molecular biology techniques.
• Excellent written and spoken English skills.
• Ability to work effectively in a collaborative, international, and interdisciplinary environment.

TU Delft (Delft University of Technology)

Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context.

At TU Delft we embrace diversity as one of our core values and we actively engage to be a university where you feel at home and can flourish. We value different perspectives and qualities. We believe this makes our work more innovative, the TU Delft community more vibrant and the world more just. Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale. That is why we invite you to apply. Your application will receive fair consideration.

Challenge. Change. Impact!

Faculty Applied Sciences

With more than 1,100 employees, including 150 pioneering principal investigators, as well as a population of about 3,600 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. To that end, we educate innovative students in broad Bachelors and specialist Masters programmes with a strong research component. Our scientists conduct ground-breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics. We are also training the next generation of high school teachers.

about this vacancy or the selection procedure, please contact Chirlmin Joo, via C.Joo@tudelft.nl.

Application procedure

Are you interested in this vacancy? Please apply no later than 13 April 2025 upload the following documents:

• CV
• Motivational letter

You can address your application to Chirlmin Joo.

Doing a PhD at TU Delft requires English proficiency at a certain level to ensure that the candidate is able to communicate and interact well, participate in English-taught Doctoral Education courses, and write scientific articles and a final thesis. For more details please check the Graduate Schools Admission Requirements. Please note:

• You can apply online. We will not process applications sent by email and/or post.
• A pre-employment screening can be part of the selection procedure.
• For the final candidates, a knowledge security check will be part of the application procedure. For more information on this check, please consult Chapter 8 of the National Knowledge Security Guidelines. We carry out this check on the basis of legitimate interest.
• Please do not contact us for unsolicited services.

Faculty/Department: Faculty of Mechanical Engineering Salary range: €2901 - €3707 Hours per week: 38 FTE: 1,0 Submission is possible until: 13 Apr 2025 ID job: 1949